CPAP titration failure is not equivalent to long-term CPAP treatment failure in patients with obesity hypoventilation syndrome: a case series

AC Lastra, JF Masa, B Mokhlesi - Journal of Clinical Sleep Medicine, 2020 - jcsm.aasm.org
Study Objectives: Medium and long-term trials comparing continuous positive airway
pressure (CPAP) with noninvasive ventilation in patients with obesity hypoventilation
syndrome have shown no differences in outcomes. However, it remains unclear whether
CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration,
despite optimization of upper airway obstructive events or if maximum CPAP pressure is
reached. We aimed to examine the effects of 6 weeks of home CPAP therapy on gas …
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